Malaria — Resurgence, Resistance, and Research

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Abstract
If we take as our standard of importance the greatest harm to the greatest number, then there is no question that malaria is the most important of all infectious diseases.— Sir Macfarlane Burnet Natural History of Infectious Disease In the 16 years since malaria was reviewed in this section of the Journal,1 major developments have occurred that have begun a new chapter in the 3500-year-old recorded history of malaria. There has been a worldwide resurgence in disease transmission, and the concept that malaria could be eradicated through a program of dichlorodiphenyl trichloroethane (DDT) spraying and chemoprophylaxis has been . . .