Klinische Erfahrungen mit einem neuen intravenös applizierbaren Immunglobulin-Präparat

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Abstract
A new Ig preparation (Sandoglobulin) was administered to 20 patients, a total of 49 infusions at a dose averaging 12.6 g .gamma.-globulin/infusion. Twelve patients had congenital or acquired Ig deficiency, in some very severe. An in-vivo recovery, on the basis of an estimated plasma volume, averaged 85% of expected values. Half-life on repeat substitutions was over 20 days. There were no severe side effects or changes in important biochemical values. In 1 woman with an antibody deficiency syndrome, fever regularly developed after several infusions, but it always fell to normal spontaneously after several hours. In 2 women followed for some time, both with severe antibody deficiency syndrome, there was a definite decrease in severity and frequency of pulmonary infections.