Decreased Somal Size of Deep Layer 3 Pyramidal Neurons in the Prefrontal Cortex of Subjects With Schizophrenia
Open Access
- 1 May 2001
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 58 (5) , 466-473
- https://doi.org/10.1001/archpsyc.58.5.466
Abstract
WORKING memory is impaired in persons with schizophrenia,1,2 and these abnormalities are associated with altered function of the dorsal prefrontal cortex (dPFC).3,4 In addition, studies in nonhuman primates indicate that working memory requires the integrity of dPFC connections with other cortical regions and the thalamus.5,6Keywords
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