Abstract
Summary Reserpine stimulates transport of glucose and Na by everted segments of rat small intestine. The drug is effective both in vivo and in vitro. Adrenal demedullation does not diminish the response to reserpine injections, but dichloroisoproterenol blocks the effects of reserpine. It is concluded that reserpine acts directly on the gut, and that its effects are at least in part consequent to release of catecholamines from storage sites in the intestine.