Paraproteinemia in Normal Family Members of Eight Cases with Primary Intestinal Lymphomas in Iraq

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Abstract
Normal family members of 8 patients with paraproteinemia of the primary intestinal lymphoma were investigated by immunoelectrophoresis for Ig[immunoglobulin]A H-chain pattern. IGA H-chain pattern was demonstrated in 4 families only, of different members, but all are of the 1st degree relationship. Detailed clinical, laboratory, radiological and histopathological findings of those 8 cases were suggestive of malabsorption. Of the 129 normal family members of the 8 cases, 23 cases (17.8%) had abnormal Ig in their sera. There may be a hereditary factor which is responsible for production of .alpha.-chain diseases.