Effect of Pyrazinamide and Pyrazinoic Acid on Urate Clearance and Other Discrete Renal Functions.
- 1 October 1957
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 96 (1) , 264-267
- https://doi.org/10.3181/00379727-96-23450
Abstract
Summary 1. The effect of pyrazinamide and pyrazinoic acid on the renal clearance of urate, inulin and p-aminohippurate, in some instances also TmPAH, was studied in 10 human subjects. 2. A rapid and marked reduction in urate clearance was noted, without decrease in the filtered urate load. The implications as to the renal mechanisms regulating urate excretion are discussed. 3. Data indicating that the effect of pyrazinamide is ascribable largely to the action of pyrazinoic acid are presented.Keywords
This publication has 2 references indexed in Scilit:
- Paradoxical Retention of Uric Acid by Uricosuric Drugs in Low Dosage.Experimental Biology and Medicine, 1955
- Ultrafiltrability of Plasma Urate in Man.Experimental Biology and Medicine, 1953