Release of C14-Histamine From Stomach and Intestine on Feeding

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Abstract
Twenty-four male rats were divided into two groups of equal body weight. Food was withdrawn for approximately 16 hours when a subcutaneous injection of C14-2-l-histidine was made. Forty-eight hours after the withdrawal of food one group was fed for 24 hours and decapitated, the other group was fasted for the entire 72 hours and decapitated. The C14-histamine in the entire glandular stomach and the entire small intestine was decreased by feeding to the extent of 52% and 30%, respectively. Although some loss may have occurred as a result of desquamation, it is concluded that most of the loss of C14 histamine from the stomach and intestinal mucosa on feeding was due to its release into the blood stream.

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