DEPLETION OF ADRENAL ASCORBIC ACID AND CHOLESTEROL: A COMPARATIVE STUDY1

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Abstract
The effects of ACTH and exposure to cold on the concentration of adrenal ascorbic acid and cholesterol were studied in several species. Exposure to severe cold produced significant depression of adrenal ascorbic acid in opossums and dogs, but failed to do so in frogs, toads, chickens, mice, hamsters, rabbits, and cats. ACTH failed to produce such a depletion in frogs, toads, chickens, rabbits, cats, or dogs; significant depressions were observed in opossums, mice and hamsters. Adrenal cholesterol concentrations remained unchanged in most species tested, however, increases were observed in rabbits, following cold exposure, and in frogs, following ACTH treatment.