Nuclear analogs of β-lactam antibiotics. XI. Synthesis of 3-methyl-7-β-(phenoxyacetamido)-Δ3-desthiocephem-4-carboxylic acid
- 14 January 1979
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 57 (2) , 227-232
- https://doi.org/10.1139/v79-037
Abstract
Treatment of an acid with triethylamine in refluxing tert-butyl alcohol gave the decarboxylated product, which was isomerized to the desired .DELTA.3 isomer using DBN [1,5-diazabicyclo[4.3.0]-5-nonene]. Reduction of the azido functions followed by coupling to phenoxyacetic acid and debenzylation gave 2 acids. Attempts to prepare dienic cephalosporins failed. The halogenation of 2 compounds was studied and discussed.This publication has 3 references indexed in Scilit:
- Nuclear analogs of β-lactam antibiotics. X. Synthesis of 2-substituted desthiocephalosporinsCanadian Journal of Chemistry, 1979
- Nuclear analogs of β-lactam antibiotics. VII. Synthesis of 2-isocephemsCanadian Journal of Chemistry, 1977
- Nuclear analogs of β-lactam antibiotics. VI. Synthesis of N-2-isocephemsCanadian Journal of Chemistry, 1977