Effect of Prednisolone and Triiodothyronine on Thyroid Function in Hyperthyroidism

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Abstract
The effect on thyroid function of administering cortical steroids and triiodothyronine has been studied in cases of hyperthyroidism. After 7 days of prednisolone medication there was a significant depression of the uptake of radioactive iodine by the thyroid gland and a fall in the protein-bound iodine in serum. By supplying thyrotropin, a thyroid response could be elicited in the presence of a high level of adrenal steroids. No significant depression of the radioiodine uptake or of the level of protein-bound iodine was observed with the same methods when triiodothyronine was given.