Reduction of Granulocyte-Macrophage Progenitor Cells (CFU-C) and Fibroblastoid Colony-Forming Units (CFU-F) by Leukemic Cells in Human and Murine Leukemia

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Abstract
The number of bone marrow granulocyte-macrophage progenitor cells (CFU-C [granulocytic progenitor cells]) and fibroblastoid colony-forming units (CFU-F) was significantly smaller in acute leukemia patients. To analyze the mechanism by which CFU-C and CFU-F were reduced, the study on murine myeloid leukemia was conducted. In murine leukemia, bone marrow CFU-C and CFU-F decreased in number in correlation with the proliferation of leukemic cells. Murine leukemic cells suppressed the growth of CFU-C and CFU-F in the mixed culture of leukemic cells and normal murine marrow cells. Leukemic cell-conditioned medium inhibited the growth of CFU-F. Murine leukemic cells themselves and/or humoral factors produced by them apparently give inhibitory effects on the growth of CFU-C and CFU-F.