Widespread γ-secretase activity in the cell, but do we need it at the mitochondria?
- 4 March 2005
- journal article
- review article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 328 (1) , 1-5
- https://doi.org/10.1016/j.bbrc.2004.12.131
Abstract
No abstract availableKeywords
This publication has 57 references indexed in Scilit:
- Identification of a New Presenilin-dependent ζ-Cleavage Site within the Transmembrane Domain of Amyloid Precursor ProteinJournal of Biological Chemistry, 2004
- Take five—BACE and the γ-secretase quartet conduct Alzheimer's amyloid β-peptide generationThe EMBO Journal, 2004
- Reconstitution of γ-secretase activityNature Cell Biology, 2003
- Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase ComplexNeuron, 2003
- Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptidesTrends in Cell Biology, 2003
- The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience, 2002
- Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cellsNature Cell Biology, 2000
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseNature, 1995
- The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorNature, 1987
- Amyloid plaque core protein in Alzheimer disease and Down syndrome.Proceedings of the National Academy of Sciences, 1985