A Convenant Synthesis of 6-Formyl-5-Deazapterin

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Abstract
6-Formyl-5-deazapterin, a key intermediate for the synthesis of a variety of 5-deaza analogues of folic acid, has been conveniently prepared by palladium-catalyzed coupling of 2-pivaloyl-6-bromo-5-deazapterin with siyrene, followed by ozonolysis of the resulting 6-styryl derivative, and final hydrolysis of the pivaloyl grouping. The penultimate compound in this sequence, 2-pivaloyl-6-formyl-5-deazapterin, is a partictularly convenient (and soluble) intermediate for further synthetic operations.