Centrosomal pre-integration latency of HIV-1 in quiescent cells
Open Access
- 10 September 2007
- journal article
- Published by Springer Nature in Retrovirology
- Vol. 4 (1) , 63
- https://doi.org/10.1186/1742-4690-4-63
Abstract
Human immunodeficiency virus type 1 (HIV-1) efficiently replicates in dividing and non-dividing cells. However, HIV-1 infection is blocked at an early post-entry step in quiescent CD4+ T cells in vitro. The molecular basis of this restriction is still poorly understood. Here, we show that in quiescent cells, incoming HIV-1 sub-viral complexes concentrate and stably reside at the centrosome for several weeks. Upon cell activation, viral replication resumes leading to viral gene expression. Thus, HIV-1 can persist in quiescent cells as a stable, centrosome-associated, pre-integration intermediate.Keywords
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