Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin
- 1 October 1995
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 140 (10) , 1849-1854
- https://doi.org/10.1007/bf01384347
Abstract
HIV-1 acquires cell membrane proteins during budding. The cell membrane proteins (CMP) profile of laboratory HIV-1 strains grown in different host cells was established, by using an immobilized antibody capture (IAC), to verify whether CMPs present on HIV-1 correlate with its host cell origin. HIV-1 grown in different cell lines incorporates cell markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the distinctive expression of these antigens on the host cells. Furthermore, also T-tropic and monocytotropic HIV-1 strains display host cell specific markers, supporting the hypothesis that virus associated CMPs are a marker of host cell origin.Keywords
This publication has 24 references indexed in Scilit:
- HIV Type 1 Grown on Interferon γ-Treated U937 Cells Shows Selective Increase in Virion-Associated Intercellular Adhesion Molecule 1 and HLA-DR and Enhanced Infectivity for CD4-Negative CellsAIDS Research and Human Retroviruses, 1995
- Unidirectional budding of HIV-1 at the site of cell-to-cell contact is associated with co-polarization of intercellular adhesion molecules and HIV-1 viral matrix proteinAIDS, 1995
- Treatment of HIV-infected fibroblasts with human leukocyte antigen (HLA)-DR-inductive cytokines leads to infectious virions with newly acquired HLA-DRAIDS, 1994
- Comparison of viral burden and phenotype of HIV-1 isolates from lymph nodes and bloodAIDS, 1994
- Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurementsJournal of General Virology, 1994
- A Simple and Reliable Method to Detect Cell Membrane Proteins on Infectious Human Immunodeficiency Virus Type 1 ParticlesThe Journal of Infectious Diseases, 1994
- A Cross-Sectional Comparison of Persons with Syncytium- and Non-Syncytium-Inducing Human Immunodeficiency VirusThe Journal of Infectious Diseases, 1993
- Synthetic Peptide Analogs of Intercellular Adhesion Molecule 1 (ICAM-1) Inhibit HIV-1 Replication in MT-2 CellsAIDS Research and Human Retroviruses, 1993
- Structure—function relationships of the HIV-1 envelope V3 loop tropism determinantAIDS, 1993
- Host cell membrane proteins on human immunodeficiency virus type 1 after in vitro infection of H9 cells and blood mononuclear cells. An immuno-electron microscopic studyJournal of General Virology, 1993