THE METABOLIC DETOXICATION OF 2,4-DINITROPHENOL BY FUSARIUM OXYSPORUM

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Abstract
Dinitrophenol (DNP) was found to be reduced to the less toxic 2-amino-4-nitrophenol and its isomer 4-amino-2-nitrophenol by Fusarium oxysporum (Schl.) em. Snyder and Hansen. There were indications that these compounds can also be altered by the organism.The greatest reduction of DNP occurred during the first 20 days of incubation at pH 7.1 under the conditions of the experiments. The growth of F. oxysporum and the reduction of DNP were stimulated by sodium nitrate, increasing to a concentration of 1.2%. F. oxysporum produced 2,4-dinitrophenol in media treated with synthetic 2-amino-4-nitrophenol, indicating the presence of a reversible nitro-reducing system in this organism.The possible effect of the reduction of DNP on the invasion of treated wood by wood-rotting fungi is suggested and the significance of this in the problem of wood-preservation is indicated.