THE EFFECT OF ADRENOCORTICOTROPHIN ON THE NUCLEIC ACID METABOLISM OF THE RAT ADRENAL GLAND
- 30 June 1965
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 32 (3) , 303-312
- https://doi.org/10.1677/joe.0.0320303
Abstract
SUMMARY: Treatment of female rats with adrenocorticotrophin (ACTH) increased the RNA content of the adrenal glands progressively during a period of 3 days, the DNA content increased only after prolonged administration. By contrast, ACTH caused a decrease in the uptake of [32P]orthophosphate into the total RNA of the gland and into most of the RNA fractions of the subcellular components. A method of analysis for RNA and DNA based on the Schmidt-Thannhauser procedure has been evolved which eliminates extraction of nucleic acid by lipid solvents.Keywords
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