Comparison of Bumetanide and Hydrochlorothiazide on Renal Potassium and Hydrogen Ion Excretion

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Abstract
The renal electrolyte excretion pattern of bumetanide was compared with that of hydrochlorothiazide in dogs anesthetized with pentobarbital. The bumetanide-treated animals, mean Na excretion rose to 12% of the filtered load; hydrochlorothiazide increased Na excretion to 4% of the filtered load. After bumetanide, urine pH fell from 6.1 to 5.1 and net H+ excretion increased significantly. After hydrochlorothiazide, urinary pH went from 6.4 to 7.4, and there was no change in net H+ excretion. K excretion rose to 106 .+-. 22 .mu.eq/min with bumetanide and to 99 .+-. 17 .mu.eq/min with hydrochlorothiazide. These changes in electrolyte excretion occurred despite lack of changes in arterial blood gases, arterial blood pressure and glomerular filtration rate. Bumetanide did not exert an inhibitory effect on K excretion under conditions of K loading. Bumetanide appears to produce a higher urinary Na+:K+ ratio with a lower pH than hydrochlorothiazide. Renal K+ excretion in response to sulfamoyl diuretics is probably not solely dependent on the rate of Na excretion.

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