Thrombin Time Dilution Test: A Simple Method for the Control of Heparin Therapy

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Abstract
A modification of the thrombin time test (TT), which permits quantitative measurement of plasma heparin activity during therapy is described. The prolonged TT of plasma containing heparin can be corrected by dilution with platelet-rich plasma (PRP). Clinical heparin activity is considered adequate when prolonged TT of the plasma can be corrected at dilutions of from 1:4 to 1:8 (±20%). In vitro studies of 30 PRP samples containing different amounts of heparin showed that 1:4 and 1:8 dilutions did not correct prolonged TT (P*Presented in part at the Vlth International Congress of Hemostasis and Thrombosis, Philadelphia, Pa., June, 1977.