Endogenous type C retroviral sequences of mice are organized in a small number of virus-like classes and have been acquired recently

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Abstract
Endogenous type C virus-related sequences of mice were studied by annealing Moloney murine leukemia virus DNA to agarose gel blot transfers of uninfected mouse of cell DNA which was cleaved with restriction enzymes. Many of the endogenous murine leukemia virus-related sequences in mice consist of 2 organizational classes that are integrated into many different loci. Both classes resemble standard murine leukemia virus proviral DNA size and sequence organization. All lines of inbred mice examined contained both organizational classes, as did feral isolates of Mus musculus domesticus. A related Asian subspecies, M. musculus molossinus, contained different organizational classes of endogenous murine leukemia virus-related sequences. Among inbred strains and feral isolates of M. musculus domesticus, the murine leukemia virus-related sequences were present at different loci. Evidently most of these sequences were acquired recently during subspeciation and inbreeding.