RNA as a target for small-molecule therapeutics
- 1 January 2005
- journal article
- Published by Informa Healthcare in Expert Opinion on Therapeutic Patents
- Vol. 15 (1) , 49-62
- https://doi.org/10.1517/13543776.15.1.49
Abstract
Natural antibiotics that specifically target RNA components of the bacterial ribosome set precedence for RNA-directed small-molecule drugs. Structured domains of functional RNAs in bacteria and viruses have thus attracted attention as targets for the discovery of novel anti-infectives. Whereas a growing number of RNA-directed ligands have been reported in the literature, creating synthetic molecules that combine high affinity with selectivity for a specific RNA target remains a key challenge. Ongoing discovery efforts towards this goal, combined with the increasing knowledge of the factors that govern small-molecule recognition of RNA folds, will prepare the ground for the development of novel RNA-targeted therapeutics.Keywords
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