Oxidized low‐density lipoprotein induces the production of interleukin‐8 by endothelial cells

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Abstract
The concentration of interleukin‐8 (IL‐8) and RANTES was measured in culture supernatants of human EA.hy 926 endothelial cells incubated with oxidized low‐density lipoproteins (LDL). Oxidized LDL induced a 3‐fold increase in IL‐8 production (p < 0.01), whereas RANTES was not detected. Native LDL did not stimulate IL‐8 production. IL‐8 production in oxidized‐LDL‐treated cells was mediated by reactive oxygen species, as it was partially inhibited by catalase and completely inhibited by glutathione peroxidase and N‐acetylcysteine (p < 0.01).