In vitro activity and in vivo correlates of alloantigen-specific murine suppressor T cells induced by allogeneic pregnancy.
Open Access
- 1 August 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 131 (2) , 638-643
- https://doi.org/10.4049/jimmunol.131.2.638
Abstract
The fetus that results from allogeneic mating in an outbred population bears a variety of antigens against which the maternal immune system reacts, but the type of immunity that is elicited by pregnancy does not mediate graft rejection. Previous studies have demonstrated the presence of nonspecific non-thymus derived suppressor cells in the lymph nodes draining the uterus (DLN) and in the uterine decidua during first allogeneic pregnancy. These suppressor cells appear to be small lymphoid cells that inhibit the generation of cytotoxic T cells (CTL) against paternal alloantigens. We now report that after a single allogeneic pregnancy, C3H and A strain mice develop paternal alloantigen-specific suppressor T cells (Thy-1.2+, Lyt-1-2+) that are distributed systemically in peripheral lymph nodes and spleen. These suppressor cells appear to act directly on CTL generation because the frequency of CTL precursors and the ability to produce T helper cells in response to paternal alloantigens remains unchanged after allogeneic pregnancy. Suppressor T cell activity could be detected both in vitro and in vivo, and the presence of suppression in vivo was associated with increased uterine weight 5 days after inoculation of allogeneic paternal tumor cells into the uterus of pseudopregnant mice. Nevertheless, both subcutaneous and intrauterine tumor inocula regressed in these mice with suppressor T cells. The possible role of suppressor T cells in contrast to non-T suppressor cells in successful reproduction and allopregnancy-induced tolerance is discussed.This publication has 23 references indexed in Scilit:
- T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.The Journal of Experimental Medicine, 1978
- MATERNAL ALLOIMMUNISATION IN PREGNANCYTransplantation, 1978
- The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cells.The Journal of Experimental Medicine, 1977
- A suppressor T cell in the human mixed lymphocyte reaction.The Journal of Experimental Medicine, 1977
- Maternal-Fetal RelationNew England Journal of Medicine, 1976
- THE EFFECTS OF ACTIVE IMMUNIZATION ON THE DECIDUAL CELL REACTION AND ECTOPIC BLASTOCYST DEVELOPMENT IN MICEReproduction, 1975
- LONG-TERM REPRODUCTIVE PERFORMANCE OF FEMALE MICEReproduction, 1962
- Uterus of Rodents as Site for Manifestation of Transplantation Immunity Against Transplantable Tumors2JNCI Journal of the National Cancer Institute, 1962
- Specific Homograft Tolerance Induced by Successive Matings and Implications Concerning Choriocarcinoma2JNCI Journal of the National Cancer Institute, 1960
- Transplantation immunity and the immunological problem of pregnancyProceedings of the Royal Society of London. B. Biological Sciences, 1958