Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Top Cited Papers
- 1 February 2001
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 27 (2) , 153-154
- https://doi.org/10.1038/84769
Abstract
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.Keywords
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