Treatment of Neonatal Osteomyelitis with Cloxacillin in Combination with Fusidic Acid

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Abstract
Four immature infants developed staphylococcal neonatal osteomyelitis. In spite of standard treatment with cloxacillin, gentamicin and surgical drainage new lesions developed in all 4 patients. Following the addition of fusidic acid no further progress was seen in any of the infants. Fusidic acid was administered i.v. for 10-14 days in a dose of 40 mg/kg per day in 2 divided doses. The therapy was well tolerated. Thoracic kyphosis in 1 patient was the only sequelae seen.