Effects of the gastric juice inhibitory substance from Streptomyces bottropensis on gastric secretion and experimental ulcerations in rats.

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Abstract
Effects of the gastric juice inhibitory substance (GIS) from the culture filtrate of Streptomyces bottropensis F4708 to several kinds of experimental gastric ulcers and gastric juice secretion in rats were studied. GIS inhibited ulceration in pylorus-ligated rats, and also markedly reduced gastric juice secretion. Moreover, it reduced aspirin-induced lesions in pylorus-ligated rats by lowering the gastric acidity. It showed a little effect on the healing of acetic acid-induced gastric ulcer. However, it isn't effective against stress-induced gastric lesions or histamine-induced ulceration. GIS reduced gastric acid secretion in vagotomized rats, and also, though with a little lowered activity, reduced gastric juice secretion in reserpine-treated rats. The protein part of GIS was proved to be important in the action of GIS but its dark brown pigment part alone could make effect. GIS lowered the body temperatures of rats.