Condylomatous tumours of vulva, vagina, and penis. Relation between histological appearance and age.

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Abstract
Among 237 cases of condyloma, 7 types of lesions were defined. Of these, 3 were found within a wide age range in both young and elderly people, namely, the common (49.4%) and the flat (2.0%) condyloma acuminatum and condyloma acuminatum of irregular outline (13.5%). Four variants fell into different age groups. Condyloma acuminaturm, showing marked cell death (5.1%) and observed exclusively among girls in the 1st decade of life, displayed numerous acidophil bodies, presumably reflecting single cell necroses. Condylomata acuminata showing marked acanthosis (16.9%) were found in patients between 12-30 yr, dysplastic condylomata acuminata (5.9%) between 20-62 yr, and proliferative (giant) condylomata acuminata (7.2%) between 31-80 yr of age. In the latter 2 groups of lesions, the inflammatory stromal infiltrate was more prominent but cytoplasmic vacuolation, often believed to be a sign of viral infection, was seen less frequently than in the remaining types. In young people, the features seen resemble a cytocidal and/or vacuolating viral infection; the dysplastic and proliferative changes observed in older patients are compatible with malignant transformation being under way.