Effect of extract from Rhei Rhizoma on adenine-induced renal failure in rats.

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Abstract
The effect of the extract from Rhei Rhizoma was examined in rats with renal failure induced by an adenine diet. On treatment with the rhubarb extract, the level of urea nitrogen and creatinine in the serum showed a significant decrease, indicating an improvement of renal function. The urea concentrations in the liver and kidney were also decreased after the treatment. In addition, administration of the rhubarb extract to rats markedly decreased the kidney weight and 2, 8-dihydroxyadenine content in the kidneys. Macroscopic aspects of the kidneys, such as the appearance of the cut surface, were improved. However, there was no statistically significant difference between the control and rhubarb extract-treated groups with regard to the number of foreign body granulomas and deposits of acicular crystals (2, 8-dihydroxyadenine).