Polymorphism of Repeated Regions of Pertactin in Bordetella pertussis , Bordetella parapertussis , and Bordetella bronchiseptica
Open Access
- 1 August 2000
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (8) , 4815-4817
- https://doi.org/10.1128/iai.68.8.4815-4817.2000
Abstract
Pertactin is an outer membrane protein expressed by Bordetella pertussis , Bordetella parapertussis , and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.Keywords
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