RADIATION ABSORBED DOSE ESTIMATES FOR O-15 RADIOPHARMACEUTICALS ((H2O)-O-15, (CO)-O-15, (OO)-O-15)

  • 1 December 1988
    • journal article
    • research article
    • Vol. 29  (12) , 1961-1970
Abstract
In preparation for measurement of regional cerebral oxygen metabolism by positron emission tomography, radiation absorbed dose estimates for 19 internal organs, blood, and total body were calculated for newborn infants following bolus intravenous administration of H2 15O and brief inhalation of C15O and O15O. Cumulated activity for each radiopharmaceutical was calculated from a compartmental model based on the known biological behavior of the compound. Values for mean absorbed dose/unit cumulated activity (S) for internal organs and total body were based on a newborn phantom. S was separately calculated for blood. Total radiopharmaceutical absorbed dose estimates necessary to measure cerebral oxygen metabolism in a 3.51-kg infant based on 0.7 mCi/kg H215O and 1 mCi/kg C 15O and O 15O were determined to be 1.6 rad to the lung (maximum organ dose), 0.28 rad to the marrow, 0.46 rad to the gonads, and 0.22 rad to total body. These values are similar to those for current clinical nuclear medicine procedures employing 99mTc in newborn infants.