The Drosophila Tumorous lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus
- 1 April 1993
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 238-238 (1-2) , 33-37
- https://doi.org/10.1007/bf00279527
Abstract
The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.Keywords
This publication has 22 references indexed in Scilit:
- Lethal(1)aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogasterDevelopmental Genetics, 1991
- Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila developmentNature, 1989
- Proto-oncogenes in Drosophila melanogasterTrends in Genetics, 1987
- l(1)hopscotch, a larval-pupal zygotic lethal with a specific maternal effect on segmentation in DrosophilaDevelopmental Biology, 1986
- Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogasterJournal of Invertebrate Pathology, 1984
- Cell Surface Changes Associated with Cellular Immune Reactions in DrosophilaScience, 1984
- Cellular immune competence of a Drosophila mutant with neoplastic hematopoietic organsJournal of Invertebrate Pathology, 1984
- Male fertility in Drosophila melanogaster: Genetics of the vermilion regionJournal of Experimental Zoology, 1983
- A genetic melanotic neoplasm of Drosophila melanogasterDevelopmental Biology, 1981
- The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs ofDrosophila melanogasterDevelopmental Biology, 1972