LOCAL CARCINOGENICITY OF SOME ENVIRONMENTALLY RELEVANT POLYCYCLIC AROMATIC-HYDROCARBONS AFTER LIFELONG TOPICAL APPLICATION TO MOUSE SKIN

  • 1 January 1980
    • journal article
    • research article
    • Vol. 50  (3) , 266-274
Abstract
Six environmentally relevant polycyclic aromatic hydrocarbons were tested in dose-response experiments of topical application to mouse skin with regard to local carcinogenicity: benzo(a)pyrene (BaP); benzo(b)- (BbF), benzo(j)- (BjF) and benzo(k)fluoranthene (BkF); indeno(1,2,3-cd)pyrene (IP); cyclopentadieno(cd)pyrene (CP); and coronene (COR). BaP and BbF were carcinogenic, BjF and CP were weakly carcinogenic and BkF, IP and COR showed no cancer-inducing effects. In the dose range investigated BbF has about 1/3 and CP about 1/20 of the activity of BaP.