AKR Thymic Lymphomas Involving Mink Cell Focus-Inducing Murine Leukemia Viruses Have a Common Region of Provirus Integration

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Abstract
Newly acquired proviruses related to a mink cell focus-inducing murine leukemia virus were detected in low copy number in restriction endonuclease-digested DNA from thymic lymphomas of AKR/J mice. These extra proviruses were not present in DNA of either normal thymus or leukemic brain tissues. Extra tumor-specific DNA fragments generated by restriction endonucleases either were identical in size or fell into similar size classes, suggesting a common site(s) of provirus integration. Characterization of extra EcoRI DNA fragments for mink cell focus-inducing viral sequences revealed that all of them contained large terminal repeat sequences and that a significant number represented proviruses with deletions.