Stereoselective reduction of β,δ-diketo esters derived from tartaric acid. A facile route to optically active 6-oxo-3,5-syn-isopropylidenedioxyhexanoate, a versatile synthetic intermediate of artificial HMG Co-A reductase inhibitors.
- 1 January 1993
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 34 (3) , 513-516
- https://doi.org/10.1016/0040-4039(93)85115-d
Abstract
No abstract availableThis publication has 16 references indexed in Scilit:
- Enantioselective synthesis of .beta.-hydroxy .delta.-lactones: a new approach to the synthetic congeners of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitorsThe Journal of Organic Chemistry, 1991
- Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductaseJournal of Medicinal Chemistry, 1991
- Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitorTetrahedron Letters, 1990
- A highly stereoselective route to the four stereoisomers of a six-carbon synthonTetrahedron: Asymmetry, 1990
- A facile entry to β,δ-diketo and syn-β,δ-dihydroxy estersTetrahedron Letters, 1988
- Enantioselective construction of dialkylcarbinols: synthesis of (-)-5-hexadecanolideJournal of the American Chemical Society, 1987
- Enantioselective ring construction: synthesis of (+)-estrone methyl etherThe Journal of Organic Chemistry, 1987
- Preparation of .beta.-keto esters by 4-DMAP-catalyzed ester exchangeThe Journal of Organic Chemistry, 1985
- Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductaseJournal of Medicinal Chemistry, 1985
- 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. I. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivativesJournal of Medicinal Chemistry, 1985