Identification of a second interferon-regulated murine Mx gene.
Open Access
- 1 October 1988
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 8 (10) , 4524-4528
- https://doi.org/10.1128/mcb.8.10.4524
Abstract
The murine influenza virus resistance locus Mx consists of more than one interferon-responsive transcription unit. We isolated clones of the transcripts of a second Mx gene (Mx2) which is closely linked to the well-characterized resistance gene and determined their sequences. Mx2 mRNA is more than 90% identical to Mx1 mRNA in the region corresponding to the amino termini of the encoded proteins. Mx2 mRNAs of mouse strains BALB/c and CBA have open reading frames apparently interrupted by mutations. Interferon-treated cells from strain A2G and other influenza virus-resistant strains failed to express detectable amounts of Mx2 transcripts.This publication has 17 references indexed in Scilit:
- Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter.Molecular and Cellular Biology, 1988
- Transport of the Murine Mx Protein into the Nucleus Is Dependent on a Basic Carboxy-Terminal SequenceJournal of Interferon Research, 1987
- Interferon-induced Mx protein: a mediator of cellular resistance to influenza virus.1987
- Transcriptional activation of the mouse Mx gene by type I interferon.Molecular and Cellular Biology, 1986
- Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virusCell, 1986
- Mx-dependent resistance to influenza viruses is induced by mouse interferons α and β but not γVirology, 1984
- Gene expression in rat brainNucleic Acids Research, 1983
- Determination of Nucleotide Sequences in DNAScience, 1981
- Inborn Resistance of Mice to OrthomyxovirusesPublished by Springer Nature ,1981
- A new method for sequencing DNA.Proceedings of the National Academy of Sciences, 1977