The Development and Evaluation of an Attenuated Measles Virus Vaccine

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Abstract
The steps in the development and evaluation of an attenuated measles virus vaccine have been reviewed. Three years experience with such a vaccine has been briefly recounted. The results of these investigations demonstrate that adaptation of the Edmonston strain of measles virus to chick embryo cell tissue culture has decreased its pathogenicity for man while retaining its antigenicity. Whether complete attentuation can be achieved has not yet been shown, but further research is in progress with this as one objective.