Studies on Isothiazoles. IV. A New Synthetic Route to 4-Cyanoisothiazoles
- 1 April 1968
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 41 (4) , 965-971
- https://doi.org/10.1246/bcsj.41.965
Abstract
4-Cyanoisothiazoles have been prepared by a novel procedure which comprises the reacreaction of β-cyano enamines with thionyl chloride or sulfur monochloride. The reaction proceeds favorably in nonpolar solvents or in the absence of solvent. However, the cyclization did not occur in dimethylformamide and instead an amidine derivative was isolated. The preparations of the corresponding isothiazole-4-carboxylic acids are also described briefly.Keywords
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