Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II): oxygen carrier under physiological conditions
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 2,p. 275-278
- https://doi.org/10.1039/dt9850000275
Abstract
A novel and amphiphilic 5,10,15,20-tetraphenylporphyrinatoiron complex substituted with phosphocholine groups, 5,10,15,20-tetra{α,α,α,α-o-[2′,2′-dimethyl-20′-(2″-trimethylammonioethyl phosphonatoxy)eicosanamido]phenyl}porphyrinatoiron(II)(lipid-heme), has been synthesized. The lipid-heme formed a stable liposome with a phospholipid. The liposomal lipid-heme reversibly bound oxygen in neutral aqueous media at 37 °C, and its oxygen-binding rate and affinity were similar to those of red blood cells.This publication has 5 references indexed in Scilit:
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