Alterations in Renal Hemodynamics and Function in Separate Kidneys During Stimulation of Renal Artery Nerves in Dogs

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Abstract
The renal artery nerves of the left kidney of 9 dogs were stimulated and the effects on renal hemodynamics and renal function were detd. by clearance, tubular saturation and extraction technics. The right kidney was unstimulated and served as a control. Source of stimulation was a sinusoidal wave alternating current stimulator delivering from 4 to 14 volts at from 2 to 4 cps., or a Harvard inductorium delivering from 10 to 25 v. at 30 impulses/sec. In the stimulated kidney the following were reduced filtration rate, urine flow, blood flow, Tm-PAH, Tm-glucose, extraction percentages of creatinine and PAH, filtration rate per unit of tubular excretory tissue (filtration/Tm-PAH) and perfusion of active tubules with blood (RBF/Tm-PAH). The extraction percentage of O2 and filtration rate per unit of tubular reabsorptive tissue (filtration/Tm-glucose) were consistently increased. No marked alterations in kidney function occurred in the control kidney, except a slight drop in filtration rate and renal blood flow. India ink injd. into the circulation of the 2 kidneys during stimulation of the I was uniformly distributed in the control kidney. In the stimulated kidney, regions of ischemia (infarcts) involving both cortex and medulla were apparent, alongside regions heavily engorged with ink. Renal artery nerve stimulation produced a random closing off of nephrons through afferent arteriolar constriction frequently concentrated enough to be visible as infarcts. Efferent arteriolar constriction may have occurred. Blood was not shunted from the cortex to the medulla in any region.

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