STUDIES ON THE ENHANCEMENT OF RAT ISLET ALLOGRAFTS

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Abstract
SUMMARY Attempts to improve the induction of immunological enhancement of (AS × August)F1 pancreatic islet allografts in diabetic AS rats have been carried out. First, by treating the diabetic AS recipient with enhancing serum obtained from AS rats with functioning enhanced (AS × August)F, islet allografts. In these rats only 1 of 5 islet allografts had a prolonged survival, the other 4 being rejected by 2 days. Second, by transplanting (AS × August)F1 islet allografts into diabetic AS rats bearing functioning enhanced (AS × August)F1 cardiac allografts. All of these islet allografts were rejected by 2 days.