Effect of Serotonin on Bethanechol-Stimulated Gastric Pepsin Secretion in Dogs

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Abstract
The effect of serotonin on bethanechol-stimulated gastric pepsin secretion was evaluated with regard to dose-response kinetics and receptor mediation. A low dose of exogenous serotonin produced a stimulation (0.5 μg/kg/min), whereas inhibition was found for higher doses (5–10 μg/kg/min). The inhibition was non-competitive and could be significantly counteracted by (J-adrenergic blocking drugs. This study confirms results obtained during pentagastrin stimulation and supports the concept that serotonin acts via sympathetic nerves to release noradrenaline.