METABOLISM OFN-ACETYL-L-ASPARTIC ACID IN MICE
- 1 June 1966
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 44 (6) , 783-789
- https://doi.org/10.1139/o66-096
Abstract
Labeled N-acetyl-L-aspartic acid was injected intraperitoneally and intracerebrally into mice. Its metabolism was studied at different time intervals after injection by collecting CO2and by identifying the radioactive metabolites in urine. The localization of injected labeled N-acetyl-L-aspartic acid and of L-aspartic acid was studied by autoradiography. The results show that N-acetyl-L-aspartic acid does not cross the blood–brain barrier, is rapidly metabolized, and that some is excreted unchanged through the kidneys. It can be concluded that N-acetyl-L-aspartic acid is synthesized in the brain and is rapidly metabolized in the body.Keywords
This publication has 3 references indexed in Scilit:
- AUTORADIOGRAPHIC STUDIES OF THE DISTRIBUTION OF 1-AMINOCYCLOPENTANE CARBOXYLIC ACID IN NORMAL AND CANCEROUS MICECanadian Journal of Biochemistry and Physiology, 1962
- STUDIES ON FREE AMINO ACIDS IN HUMAN BRAINThe Journal of Biochemistry, 1960
- Studies on the Role of N-Acetylaspartic Acid in Mammalian BrainThe Journal of general physiology, 1959