A new macrocyclic hexaamine ligand for the dissolution of human inorganic calculi.
- 1 January 1985
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 33 (2) , 655-661
- https://doi.org/10.1248/cpb.33.655
Abstract
A newly synthesized 18-membered hexaamine carrying an acetate moiety on each nitrogen, L2 [1,4,7,10,13,16-hexacarboxymethyl-1,4,7,10,13,16-hexaazacyclooctadecane], was a more efficient dissolving agent than EDTA for human urinary calculi whose major components are CaPO4 and MgPO4. L2 is a good chelating agent for Ca2+ and Mg2+, and this chelating action is presumably responsible for the dissolution of inorganic calculi.This publication has 4 references indexed in Scilit:
- Macrocyclic polyamines as calculi solubilizers.CHEMICAL & PHARMACEUTICAL BULLETIN, 1983
- Intermittent Irrigation System for Dissolution of Renal Calculi Monitored by ComputerJournal of Urology, 1982
- Macromonocyclic polyamines as biological polyanion complexons. 2. Ion-pair association with phosphate and nucleotidesJournal of the American Chemical Society, 1982
- Macromonocyclic polyamines as specific receptors for tricarboxylate-cycle anionsJournal of the American Chemical Society, 1981