Role for p53 in Gene Induction by Double-Stranded RNA
Open Access
- 15 August 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (16) , 7774-7777
- https://doi.org/10.1128/jvi.75.16.7774-7777.2001
Abstract
Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.Keywords
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