Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia.
Open Access
- 1 September 1979
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 64 (3) , 866-869
- https://doi.org/10.1172/jci109535
Abstract
In an individual homozygous for G gamma-delta beta-thalassemia, a physical alteration in gamma-globin gene organization was detected by restriction enzyme mapping. The data indicated that the absence of A gamma-globin chains resulted from extension of the DNA deletion from the delta beta-globin gene region into the gamma-globin gene region rather than a functional disturbance of gamma-gene expression.This publication has 20 references indexed in Scilit:
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