Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.
- 1 November 1983
- journal article
- Vol. 35 (6) , 1086-9
Abstract
A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.This publication has 9 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Mapping the ?-globin genes in HB J Mexico carriersHuman Genetics, 1982
- The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequencesNature, 1982
- Nonrandom association of polymorphic restriction sites in the β-globin gene clusterProceedings of the National Academy of Sciences, 1982
- A common mutant EcoRI restriction endonuclease site in the 5' flanking portion of the human alpha-globin gene.Proceedings of the National Academy of Sciences, 1981
- Highly variable regions of DNA flank the human α globin genesNucleic Acids Research, 1981
- Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.Proceedings of the National Academy of Sciences, 1980
- The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletionsCell, 1980
- Insertion of synthetic copies of human globin genes into bacterial plasmidsNucleic Acids Research, 1978