The Banting Memorial Lecture 1965: Some Current Controversies in Diabetes Research

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Abstract
Among the disputed questions considered in this presentation are relationships between the known metabolic abnormalities in diabetes and the development of microangiopathy, and insulin antibodies and nodular glomerulosclerosis; sensitivity to insulin and availability of insulin in idiopathic diabetes mellitus and in other conditions associated with impaired glucose tolerance; the role of pituitary growth hormone in the etiology of idiopathic diabetes; the status of "bound insulin," n.A, etc.; the identification of the "synalbumin" insulin antagonist as the B chain of insulin. Also included are the presentation of data on insulin- and growth hormone-secretory responses to glucose loading in obese and nonobese diabetic and nondiabetic subjects and a discussion of the interrelationships among the peptide hormones, glucose and free fatty acids in blood.