Similarities between baboon and human blood clotting

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Abstract
Sixteen baboons, 8 males and 8 females, were used in the examination of the blood clotting mechanism in this ani?mal for the purpose of contrasting these studies with certain human and canine tests. Tests performed included the silicone clotting time, Lee-White clotting time, prothrombin time (one-stage, whole and di?luted plasma), prothrombin consumption time, fibrinogen concentration, platelet count with phase microscopy, and tests for profibrinolysin and fibrinolysin. Results of the clotting tests of the baboon appear to in?dicate that they closely resemble the results found in man. Only with the accelerated silicone coagulation time, increased Hageman factor activity, and the lack of activation of profibrinolysin by streptokinase did we ob?serve differences in the 2 species. These findings would suggest that the coagulation mechanism of the baboon would serve as a good experimental model to test the manipulation of the various aspects of coagulation mechanisms.