Inhibition of exogenous mRNA translation in a cell-free system by chromatin peptides from calf thymus
- 1 January 1980
- journal article
- research article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 6 (1) , 27-29
- https://doi.org/10.1007/bf00775750
Abstract
Low molecular weight chromatin peptides isolated from calf thymus by affinity chromatography on DNA-cellulose inhibit significantly translation of exogenous isolated mRNA in a reticulocyte cell-free system. Translation with endogenous mRNA present in the system is not inhibited by low peptide concentrations. The data obtained combined with the previous findings suggest that chromatin peptides control gene expression at two levels: transcription and translation.Keywords
This publication has 7 references indexed in Scilit:
- Control of transcription and translation by low molecular weight peptides (deprimerones) from chromatin and poly(A)-messenger RNA Implication in the mechanism of carcinogenesisBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- Low molecular weight peptides controlling transcription are present in the calf thymus chromatin structureMolecular Biology Reports, 1977
- Low-molecular-weight peptide inhibits RNA synthesis in human leukemic and phytohemagglutinin-stimulated leukocytes and globin mRNA transcription in differentiating Friend cells.Proceedings of the National Academy of Sciences, 1977
- Stabilization of double-stranded DNA molecule by nonhistone peptidic effector from calf thymusMolecular Biology Reports, 1976
- An Efficient mRNA‐Dependent Translation System from Reticulocyte LysatesEuropean Journal of Biochemistry, 1976
- Restriction of template capacity of rat liver chromatin by a non-histone peptide from calf thymusNature, 1976
- Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitroBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975