Pharmacological study on Panax ginseng C. A. Meyer. III. Effects of red ginseng on experimental disseminated intravascular coagulation. (2). Effects of ginsenosides on blood coagulative and fibrinolytic systems.

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Abstract
The activities of seven ginsenosides isolated from Red Ginseng on blood coagulative and fibrinolytic systems closely related to disseminated intravascular coagulation were investigated in in vitro models and compared with those of standard agents (aspirin, heparin and dextran sulphate). Ginsenoside-Rg2 showed strong inhibitory activity on platelet aggregation induced by three aggregating agents (endotoxin, collagen and arachidonic acid) as compared with aspirin at a concentration of 1.0 mM. Ginsenoside-Ro inhibited the conversion of fibrinogen to fibrin induced by thrombin at concentrations of 0.1 to 1.0 mM. Ginsenoside-Ro, -Rb1, -Rb2, -Rc, -Re, -Rg1 and -Rg2 may promote the action of urokinase in the fibrinolytic system on the basis of its action on plasminogen-containing fibrin plates.